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The European Journal of Public Health 2004 14(2):151-155; doi:10.1093/eurpub/14.2.151
© 2004 by European Journal of Public Health
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Infectious Diseases

Determinants of patient delay among tuberculosis cases in Spain

M. Díez1, M.J. Bleda1, J. Alcaide2, T. Caloto3, C. Castells4, J.I. Cardenal5, A. Domínguez2, P. Gayoso6, G. Gutiérrez7, C. Huerta8, M.J. López9, T. Moreno, F. Muñoz11, C. Navarro12, M. Picó13, F. Pozo14, J.R. Quirós15, F. Robles16, J.M. Sánchez17, H. Vanaclocha18 and T. Vega19 Multicentre Project for Tuberculosis Research (MPTR) Study Group20

1 Unidad de Investigación en TB, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid 2 Dirección General de Salud Pública, Generalitat de Catalunya, Barcelona 3 Merck Sharp and Dohme de España S.A. Madrid 4 Delegación Territorial de Sanidad, Gobierno Autónomo Vasco, Bilbao 5 Dirección General de Salud Pública, Junta de Extremadura, Badajoz 6 Complejo Hospitalario Cristal-Piñor, Orense 7 Dirección General de Salud Pública, Junta de Comunidades de Castilla-La Mancha, Toledo 8 Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid 9 Dirección General de Salud, Gobierno Autónomo de La Rioja, Logroño 10 Unidad de Coordinación y Desarrollo de Investigación en Enfermería, Instituto de Salud Carlos III, Madrid 11 Hospital Universitario de Valme, Sevilla 12 Servicio de Epidemiología, Consejería de Sanidad y Consumo, Murcía 13 Dirección General de Salud Pública, Junta de Andalucía, Sevilla 14 Hospital Doce de Octubre, Madrid 15 Dirección General de Salud Pública, Principado de Asturias, Oviedo 16 Consejería de Sanidad, Consejo de Gobierno de la Ciudad Autónoma de Melilla, Melilla 17 Consejería de Sanidad, Consumo y Deportes, Consejo de Gobierno de la Ciudad Autónoma de Ceuta, Ceuta 18 Dirección General de Salud Pública, Generalitat Valenciana, Valencia 19 Dirección General de Salud Pública y Asistencia, Junta de Castilla y León, Valladolid, Spain 20 Members listed in: (National Centre for Epidemiology Server/TB Research Unit), http://193.146.50.130/uit/Grupos de Trabajo (Working Groups).htm

Background: Patient delay was investigated in a cohort of TB patients identified from May 1996 until April 1997 in 13 Autonomous Regions in Spain. The study covered almost 67% of the total Spanish population. Methods: Data were collected from clinical records. Using unconditional logistic regression with two different cut-off points to define ‘patient delay’ (the median and 75th percentile), the association between patient delay and different factors was estimated. Results: A total of 7,037 cases were included. Median and 75th percentile delays were 22 and 57 days respectively. Factors associated with patient delay greater than the median (p<0.05) were: non-respiratory symptoms of TB and age over 14 years, although the effect of age was not linear. Furthermore, an interaction was observed between intravenous drug user (IDU) and HIV status, in that, whereas patient delay was greater in IDUs than in non-IDUs among cases whose HIV status was either negative or unknown, among HIV-positive patients no such IDU-related differences were in evidence. Factors associated with extreme patient delay (greater than the 75th percentile) were essentially the same, but the above-described interaction disappeared, with IDU status showing no direct effect. In addition, likelihood of extreme patient delay increased in the case of alcoholism and female gender and decreased in the case of chronic renal failure, corticoid treatment, prison inmates and residents of old age homes. Conclusion: Although there is a universally enjoyed right to health care in Spain, some groups of TB patients could nevertheless be experiencing problems in seeking medical attention.

Keywords: HIV, patient delay, tuberculosis


Received 18 July 2002. Accepted 9 January 2003.

* Correspondence: Mercedes Díez, MD, PhD, Seconded National Expert, Poverty-related Diseases, Directorate-General for Research, European Commission, Office SDME 07/38, Square de Meeûs 8, B-1050 Bruxelles, Belgium, tel. +32 2 298 6728, fax +32 2 295 5365, e-mail: Mercedes.DIEZ-RUIZ-NAVARRO{at}cec.eu.int


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